Detalhe da pesquisa
1.
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.
Cell
; 185(13): 2213-2233.e25, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35750033
2.
HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts.
J Lipid Res
; 62: 100114, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34481829
3.
Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells.
J Lipid Res
; 58(4): 695-708, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28193631
4.
A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele.
J Neurosci
; 35(21): 8091-106, 2015 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26019327
5.
Role of STARD4 and NPC1 in intracellular sterol transport.
Biochem Cell Biol
; 94(6): 499-506, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27421092
6.
Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts.
Proc Natl Acad Sci U S A
; 108(14): 5620-5, 2011 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21436030
7.
Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect.
Traffic
; 11(5): 601-15, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20412078
8.
2-Hydroxypropyl-ß-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease.
Biochim Biophys Acta Mol Cell Biol Lipids
; 1864(10): 1545-1561, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31051283
9.
Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.
Nat Med
; 24(4): 526, 2018 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29634683
10.
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing.
Nat Med
; 23(7): 878-884, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28628110
11.
Parallel analysis of v-Src mutant protein function using reverse transfection cell arrays.
Comb Chem High Throughput Screen
; 9(9): 711-8, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17100576
12.
Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary.
PLoS One
; 7(10): e47320, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23056628
13.
Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease.
J Exp Med
; 209(13): 2501-13, 2012 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23209315
14.
STARD4 abundance regulates sterol transport and sensing.
Mol Biol Cell
; 22(21): 4004-15, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21900492
15.
Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.
PLoS One
; 5(9): e12788, 2010 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20877719
16.
The L49F mutation in alpha erythroid spectrin induces local disorder in the tetramer association region: Fluorescence and molecular dynamics studies of free and bound alpha spectrin.
Protein Sci
; 18(9): 1916-25, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19593814
17.
Sterol, protein and lipid trafficking in Chinese hamster ovary cells with Niemann-Pick type C1 defect.
Traffic
; 8(2): 130-41, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17156101
18.
Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.
J Lipid Res
; 47(2): 284-301, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16288097
19.
A novel mechanism for protein delivery: granzyme B undergoes electrostatic exchange from serglycin to target cells.
J Biol Chem
; 280(21): 20752-61, 2005 May 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-15788411